(Yes, this one is out of order. I clicked the wrong button yesterday, or something. Tomorrow’s glitch will be number eleven, though.)
No dash (that’s what the hyphen there wants to be when it grows up), because there is no abrupt change in thought in the sentence. At most, you could delete and and begin a new sentence with Though. If the object is literally named the Talisman, the capitalization works, but I see no indication of that here, and the pronoun he should not be capitalized except at the start of a sentence (or if referring to a deity, but again, that’s highly unlikely here, and if it is the case, His needs to be capitalized, too).
After all these years, the talisman was finally his, and though he knew in his heard it would be the cause of his demise, he did not care.