This one is tricky. There’s an ellipsis interrupting a nonrestrictive clause, which may cause the writer to overlook the fact that it is a nonrestrictive clause. A nonrestrictive clause, which can be omitted without changing the basic meaning of the sentence as a whole, should be separated from the rest of the sentence with commas. (Don’t blame me; I’m not the one who said we needed more jargon in these posts.) The comma after wrong does belong there. If you removed the ellipsis, this is how it would look: There was something strange, something wrong, with the children who came from that house.
Actually, something wrong may be a nonrestrictive appositive, specifically. (An appositive expands on or “renames” what comes before it.) Doesn’t matter. Either way, you need that comma after wrong.
This example, by the way, shows the correct way to indicate a dramatic pause: with an ellipsis, not a comma or an em-dash. 🙂
Change the first that to who; it refers to people, not inanimate objects.
There was something strange, something… wrong, with the children who came from that house.
(If I seem a bit more “grumpy, grouchy old man” than usual today, it’s because my clone is suffering from a horrible migraine headache caused by rapid changes in air pressure. If you’ve ever been mindlinked to someone who’s in a great deal of pain, you understand, and if not… Well, use your imagination.)