You do know what handful means as an indeterminate number, right? A small handful would be, what, three or four? I think small group works better here.
Don’t capitalize world; it’s a common (generic) noun, not a proper noun.
To improve the flow of the sentence, consider replacing to make it to a shelter with to reach a shelter.
You are one of a small group of humans to make it to a shelter meant for thousands as the world ends. Where are the noises coming from?
I realize it probably feels to the people living through it as if the world is ending, but really, it’s just the collapse of civilization/life as we know it, and the world itself will continue.